EM and fluorescence analysis in the same preparation
Posted in Hardware
Several labs have set up their own workflows for imaging the same tissue using both fluorescence and electron microscopy (EM). Zeiss just released a product, called Shuttle-and-Find, to streamline this. It’s pretty simple, just a movable chuck on which the sample is mounted in either machine. The software then finds the ROIs marked in one modality, for imaging with the second modality. (link)
The movable chuck, the “shuttle”.
The automatic software alignment, the “find”.