I’m switching to Typst. Just started. Let’s see if it lasts. But so far so good.

Years ago, I switched from Word to Overleaf for preparing manuscripts and grants. Word annoyed…

Changes are afoot. Amidst the destructive chaos of the past six months, much is uncertain, but one clear trend is that NIH is going to continue to influence the ecosystem of…

I was walking around an aquarium a couple of days ago and I saw a young person taking long videos of the fish in the tanks. Through the glass, glare and all, in…

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When I was an undergraduate, my older sister got me a job: working in the complex carbohydrate chemistry lab of a prolific heparin and heparan sulfate chemist, Bob Linhardt. In…

Volumetric Imaging of Neural Circuit Connectivity and Dynamics

?Tuesday, July 22, 2025
14:00–17:00 BST (UK time)?
Hybrid | Join us online or in person at Imperial College London (South Kensington, Royal…

This is a silly thing, but I’m going to post it here anyways. We just released our latest work on laser scan engine technology. It’s focused on how…

Much gratitude from me to this group of brilliant people pushing the frontiers of what is possible in multiphoton imaging.

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Humankind is overdue for moving past glass for state-of-the-art optics. We’re never going to be completely rid of glass, but we have been coasting on 17th century technology for 21st century applications. We have been…

When I was a kid, maybe about 12 years old, I was in my bedroom (in the basement), at my computer that I bought with my paper route money…

Pushing the frontiers of medicine, science, and technology takes highly trained people and extensive specialized infrastructure. You can’t just hire a self-taught coder off the internet and hand them…

Executive orders are powerful actions that can have catastrophic consequences. They merit thoughtful analysis and research prior to enactment.

EO 9066 interned US citizens and resulted in their loss…

I am disappointed to read comments from people who have been PIs on NIH and NSF grants for years, sometimes decades, and they don’t understand what indirect costs pay for. They’re not necessarily…

That’s a quote from Rick Rubin.

When I speak to a general audience, I sometimes show this clip (start at 2:52) from Fantastic Voyage and say:

How can we study the brain? What does it…

Check out this post today from Terrance Tao (UCLA) on Mastodon. It’s all good– T. Tao is excellent. I’m particularly interested in the posts because I’ve been working on some…

In two photon imaging, we want the detector (photomultiplier / PMT, or SiPM) to see only the green photons from the fluorescent molecules we’re interested in (e.g.,…