Active alignment for diffraction limited optics in the 1600s

In my optics classes, I often give a brief historical account of Galileo’s telescopes. A point I want to make in this post, is that part of the high performance of Galileo’s telescopes was obtained through careful final adjustments. We do the same thing with our optics, designing in correction collars, adjustable air gaps, and…



Suiting for academics

Humphrey is a gentleman. We relax together after an intense day.

This is post is about suits. Most Labrigger readers will want to skip reading this one. I did a post…



A sense of scale: web ads pay for AI/ML

Worldwide spending on all advertising is on the order of 1 trillion USD per year (source: statista). Web ad companies capture large fractions of this. For example, Meta gets about 10%, and Google gets about 20%. Then those companies invest heavily in R&D of various types, including for machine learning (ML) / artificial intelligence (AI)….



RF remapping in V2: “Nothing is an absolute reality; all is permitted”

It is both fascinating and frustrating. Large-scale receptive field remapping in V2 neurons: Work by: Sachira Denagamage, Mitchell P Morton, Anirvan Nandy

https://www.biorxiv.org/content/10.1101/2023.05.01.539001v1

Our eyes are in constant motion, yet we perceive…



Values

Ikuko Smith taught me that me that Japanese people judge others by the way they wring out a washcloth. “It says a lot about how a person was raised.” That was a new thing for me to be self conscious about, but addressable. Unlike my technique for eating corn-on-the-cob. This Iowa boy is stuck in…



When do you need a pulse compressor for multiphoton imaging?

There are different types of pulse compressors, this is clever single prism design.

Here’s a quick question I received via email that might be worth sharing: Does using a pulse compressor make a noticeable…



Reducing bureaucratic burden for academics

Many are aware of the burden of bureaucratic administrative tasks on professors. A colleague of mine called it “Death by 1000 paper cuts.” It takes time away from research and other scholarly activities, and oftentimes the time commitment is substantial, taking 20-40% of a professor’s time, depending on who you ask and what items are…



Robot arm with a 2p scope attached

Coming soon to your neuroscience lab.

Thorlabs has worked with the great Jacob Reimer to create a streamlined 2p system that is compact enough to mount on a robotic arm.



Simple time management advice for academics

Academics don’t typically receive much advice in time management during their training. Then they get a tenure-track position and are expected to figure it out. Most do indeed figure it out, but there can be pain involved. Here are some simple bits of advice, take what you find useful, ignore the rest.

The best system is…



Blackout shades for imaging rigs

Your amazing imaging rig should be operated with the room lights on. There’s no reason you need to do your work in the dark. My rigs are built lightproof. Very lightproof. We could…



Writing advice for NIH R01 grants

For those who might find it useful, I am sharing some grant-writing advice. It is specifically for writing NIH R01 grants, but many of the principles are more broadly applicable.

Advice-for-writing-your-first-R01s-SLS-1Download



A sense of scale, public vs. private universities

Private universities have many fewer undergraduate students compared to public universities. From Wikipedia, mostly 2021 numbers.

People generally understand the difference in governance between public and private schools, but they might not…



2 tips for making big lab purchases easier

Making good use of those indirect cost returns

Spending a lot of money on a big purchase can be time consuming. Whether it’s a high-power laser, an imaging system, or something else, the process…



Write it down. Analyze it now.

This piece from Eve Marder resonantes with me. Just a couple of notes to elaborate on it.

Pages from Oliver Smithies’ lab notebook

Write it down. I tell people in my lab…



Vertical histograms FTW

I might be alone in this, and I’m willing to die on this hill, but here it is:

Vertical histograms are better than all of these: violin plots, box plots, kernel density plots, beeswarm plots. (if you don’t know those terms, simply do a web search for them for examples)

Just show me the naked distribution….